Paul J Declerck Selected Research

Carboxypeptidase B2 (Thrombin Activatable Fibrinolysis Inhibitor)

1/2021	S62798, a potent TAFIa inhibitor, accelerates endogenous fibrinolysis in a murine model of pulmonary thromboembolism.
10/2018	Defective TAFI activation in hemophilia A mice is a major contributor to joint bleeding.
1/2016	Inhibition of Thrombin-Activatable Fibrinolysis Inhibitor and Plasminogen Activator Inhibitor-1 Reduces Ischemic Brain Damage in Mice.
1/2016	Haemostatic biomarkers are associated with long-term recurrent vascular events after ischaemic stroke.
11/2014	Active PAI-1 as marker for venous thromboembolism: case-control study using a comprehensive panel of PAI-1 and TAFI assays.
3/2011	High thrombin activatable fibrinolysis inhibitor levels are associated with an increased risk of premature peripheral arterial disease.
4/2007	Thrombin activatable fibrinolysis inhibitor activation peptide shows association with all major subtypes of ischemic stroke and with TAFI gene variation.

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Paul J Declerck Research Topics

Disease

16	Cardiovascular Diseases (Cardiovascular Disease) 02/2021 - 08/2002
15	Neoplasms (Cancer) 02/2021 - 08/2003
6	Thromboembolism 01/2021 - 04/2011
6	Thrombosis (Thrombus) 02/2015 - 07/2002
4	Fibrosis (Cirrhosis) 02/2021 - 01/2020
4	Hemorrhage 01/2021 - 02/2015
4	Stroke (Strokes) 01/2016 - 04/2007
3	Venous Thrombosis (Deep-Vein Thrombosis) 01/2021 - 07/2002
3	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2017 - 10/2014
3	Ischemic Stroke 01/2016 - 04/2007
2	Atherosclerosis 01/2016 - 11/2004
2	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2016 - 02/2015
2	Inflammation (Inflammations) 01/2013 - 03/2004
2	Ischemia 10/2011 - 03/2004
2	Myocardial Infarction 09/2007 - 07/2002
1	Pulmonary Embolism 01/2021
1	Animal Disease Models 01/2020
1	Hemophilia A (Haemophilia) 10/2018
1	Neoplasm Metastasis (Metastasis) 01/2017
1	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2017
1	Multiple Sclerosis 01/2017
1	Rheumatic Diseases (Rheumatism) 01/2017
1	Cerebral Infarction 01/2016
1	Brain Ischemia (Cerebral Ischemia) 01/2016
1	Infarction (Infarctions) 01/2016
1	Venous Thromboembolism 11/2014
1	Pneumonia (Pneumonitis) 01/2013
1	Acute Lung Injury 01/2013
1	Endotoxemia 04/2012
1	Autolysis 08/2011
1	Peripheral Arterial Disease 03/2011
1	Sepsis (Septicemia) 01/2008
1	Disseminated Intravascular Coagulation 01/2008
1	Hyperlipidemias (Hyperlipidemia) 02/2006
1	Obesity 01/2006
1	Insulin Resistance 01/2006
1	Hypertension (High Blood Pressure) 11/2004
1	Choroidal Neovascularization 06/2003
1	Macular Degeneration (Age-Related Maculopathy) 06/2003
1	Pathologic Neovascularization 06/2003

Drug/Important Bio-Agent (IBA)

23	Plasminogen Activator Inhibitor 1IBA 02/2021 - 07/2002
11	Plasminogen Activators (Plasminogen Activator)IBA 01/2020 - 07/2002
9	Urokinase-Type Plasminogen Activator (Urokinase)FDA Link 01/2020 - 03/2004
7	Carboxypeptidase B2 (Thrombin Activatable Fibrinolysis Inhibitor)IBA 01/2021 - 04/2007
6	FibrinIBA 01/2016 - 03/2004
5	Monoclonal AntibodiesIBA 01/2016 - 04/2011
5	SerpinsIBA 07/2010 - 08/2002
4	Thromboplastin (Tissue Factor)IBA 01/2021 - 08/2006
4	AntibodiesIBA 01/2020 - 07/2011
4	Peptides (Polypeptides)IBA 01/2020 - 02/2006
4	Tissue Plasminogen Activator (Alteplase)FDA Link 10/2018 - 02/2015
4	VitronectinIBA 06/2013 - 06/2003
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2014 - 01/2006
2	Fibrinolytic Agents (Antithrombotic Agents)IBA 09/2014 - 01/2013
2	Plasminogen InactivatorsIBA 07/2014 - 06/2003
2	AntigensIBA 03/2011 - 02/2006
2	Glucose (Dextrose)FDA LinkGeneric 01/2006 - 03/2004
1	AnticoagulantsIBA 01/2021
1	EndopeptidasesIBA 01/2020
1	Matrix Metalloproteinase 2 (Gelatinase A)IBA 01/2020
1	Immunoglobulin FragmentsIBA 01/2020
1	Factor VIII (Coagulation Factor VIII)IBA 10/2018
1	trypsin-like serine proteaseIBA 01/2017
1	Biological ProductsIBA 01/2017
1	Biomarkers (Surrogate Marker)IBA 01/2016
1	Fibrinogen (Factor I)FDA Link 01/2016
1	Proteins (Proteins, Gene)FDA Link 01/2016
1	von Willebrand FactorIBA 01/2016
1	estropipate (Ogen)FDA LinkGeneric 01/2016
1	Infliximab (Remicade)FDA Link 08/2015
1	Tetracycline (Achromycin)FDA LinkGeneric 04/2015
1	Thrombin FDA Link 02/2015
1	Antifibrinolytic Agents (Antifibrinolytics)IBA 07/2014
1	ProlactinIBA 07/2014
1	Peptide Hydrolases (Proteases)FDA Link 07/2013
1	LipopolysaccharidesIBA 01/2013
1	EpitopesIBA 08/2011
1	Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA 07/2010
1	Protein CIBA 01/2008
1	danaparoid (Orgaran)FDA Link 04/2007
1	Pharmaceutical PreparationsIBA 08/2006
1	Insulin (Novolin)FDA Link 01/2006
1	PPAR gammaIBA 01/2006
1	Interleukin-6 (Interleukin 6)IBA 03/2004
1	Messenger RNA (mRNA)IBA 06/2003

Therapy/Procedure

3	Therapeutics 01/2016 - 08/2003
1	Stents 08/2006